Signal Transducer CD24/CD24 (C-mFC) (recombinant human)

Signal Transducer CD24/CD24 (C-mFC) (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH033949.10 10 µg -

7 - 16 business days*

156.00€
E-PKSH033949.50 50 µg -

7 - 16 business days*

467.00€
 
Activity: Immobilized Human CD24-mFc(Cat#PKSH033949) at 2µg/ml (100 µl/well) can bind  Anti-Human... more
Product information "Signal Transducer CD24/CD24 (C-mFC) (recombinant human)"
Activity: Immobilized Human CD24-mFc(Cat#PKSH033949) at 2µg/ml (100 µl/well) can bind  Anti-Human CD24 mAb. The ED50 of  Anti-Human CD24 mAb is 10.1 ng/ml. Protein Construction: Recombinant Human Signal Transducer CD24 is produced by our Mammalian expression system and the target gene encoding Ser27-Gly59 is expressed with a mFc tag at the C-terminus. Sequence: Ser27-Gly59. Fusion tag: C-mFc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 40-60 kDa. Protein function: Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs. Protein function: May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin- like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. [The UniProt Consortium]
Keywords: CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, Recombinant Human Signal Transducer CD24/CD24 (C-mFC)
Supplier: Elabscience
Supplier-Nr: E-PKSH033949

Properties

Conjugate: No
Host: Human cells
Species reactivity: human
MW: 29.5 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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