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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSR030473.10 | 10 µg | - |
7 - 16 business days* |
261.00€
|
|||
E-PKSR030473.50 | 50 µg | - |
7 - 16 business days* |
689.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NCBI Reference Sequence: YP_009725309.1. Recombinant 2019-nCoV Guanine-N7 methyltransferase is... more
Product information "SARS-CoV-2 (2019-nCoV) Guanine-N7_meth Protein (His Tag), recombinant"
NCBI Reference Sequence: YP_009725309.1. Recombinant 2019-nCoV Guanine-N7 methyltransferase is produced by our E.coli expression system and the target gene encoding Ala1-Gln527 is expressed with a 6His tag at the N-terminus. The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.positive-stranded RNA genome of the coronaviruses is translated from ORF1 to yield polyproteins that are proteolytically processed into intermediate and mature nonstructural proteins (nsps). SARS-CoV 2 polyproteins incorporate 16 protein domains (nsps). The putative non-structural protein 2 (nsp2) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development. Proofreading exoribonuclease: Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. Acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens.
Keywords: | SARS-CoV-2 3'-to-5' exonuclease, Proofreading exoribonuclease, N7-guanine methyltransferase |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSR030473 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | SARS-CoV-2 |
MW: | 60 kD |
Purity: | > 85 % as determined by reducing SDS-PAGE. |
Format: | Solution |
Database Information
KEGG ID : | K24149 | Matching products |
UniProt ID : | P0DTD1 | Matching products |
Gene ID | GeneID 43740578 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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