SARS-CoV-2 (2019-nCoV) 3C-like Proteinase Protein (His Tag), recombinant

NCBI Reference Sequence: YP_009725301.1. Recombinant 2019-nCoV 3C-like Proteinase is produced by our E.coli expression system and the target gene encoding Ser1-Gln306 is expressed with a 6His tag at the N-terminus. The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3C-like proteinase cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-, -[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).