S+E+M protein (recombinant SARS-CoV-2)

Protein Construction: Recombinant SARS-CoV-2 S&M&E fusion is produced by E.coli expression system and the target gene encoding Arg319-Phe541&Arg38-Val75&Arg101-Gln222 is expressed with C-His Tag Fusion tag: C-His Endotoxin: Please contact with the lab for this information Apparent Molecular Mass: 44.7kDa. Protein function: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. Protein function: Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by binding cytoplasmic c-terminus of S (PubMed:33229438). [The UniProt Consortium]