RNA Binding Motif Protein 8A, Recombinant, Human, aa1-174, His-tag (RNA-binding Motif Protein 8A, RB

RNA Binding Motif Protein 8A, Recombinant, Human, aa1-174, His-tag (RNA-binding Motif Protein 8A, RB
Item number Size Datasheet Manual SDS Delivery time Quantity Price
R2033-08H.50 50 µg - -

4 - 22 business days

519.00€
 
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice... more
Product information "RNA Binding Motif Protein 8A, Recombinant, Human, aa1-174, His-tag (RNA-binding Motif Protein 8A, RB"
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway. [The UniProt Consortium]
Keywords: RNA-binding protein 8A, RNA-binding protein Y14, RNA-binding motif protein 8A
Supplier: United States Biological
Supplier-Nr: R2033-08H

Properties

MW: 20,9 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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