Recombinant Mouse Interleukin-4/IL-4 (C-6His)

Recombinant Mouse Interleukin-4/IL-4 (C-6His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-8642-10 10 µg - -

2 - 11 business days

424.00€
ABE-32-8642-50 50 µg - -

2 - 11 business days

704.00€
 
Source: Human Cells. MW :14.6kD. Recombinant Mouse Interleukin-4 is produced by our Mammalian... more
Product information "Recombinant Mouse Interleukin-4/IL-4 (C-6His)"
Source: Human Cells. MW :14.6kD. Recombinant Mouse Interleukin-4 is produced by our Mammalian expression system and the target gene encoding His21-Ser140 is expressed with a 6His tag at the C-terminus. Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response. Protein function: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-8642

Properties

Conjugate: No

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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