Recombinant Human Interleukin-17F/IL-17F (Human Cells)

Recombinant Human Interleukin-17F/IL-17F (Human Cells)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-8912-10 10 µg - -

3 - 11 business days*

478.00€
ABE-32-8912-50 50 µg - -

3 - 11 business days*

791.00€
 
Source: Human Cells. MW :14.9kD. Recombinant Human Interleukin-17F is produced by our Mammalian... more
Product information "Recombinant Human Interleukin-17F/IL-17F (Human Cells)"
Source: Human Cells. MW :14.9kD. Recombinant Human Interleukin-17F is produced by our Mammalian expression system and the target gene encoding Arg31-Gln163 is expressed. Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6). Protein function: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-8912

Properties

Conjugate: No

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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