Recombinant Human ICOS/CRP-1/AILIM/CD278 (C-Fc)

Recombinant Human ICOS/CRP-1/AILIM/CD278 (C-Fc)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-7878-10 10 µg - -

3 - 11 business days*

391.00€
ABE-32-7878-50 50 µg - -

3 - 11 business days*

585.00€
 
Source: Human Cells. MW :40.8kD. Recombinant Human Inducible T-cell costimulator is produced by... more
Product information "Recombinant Human ICOS/CRP-1/AILIM/CD278 (C-Fc)"
Source: Human Cells. MW :40.8kD. Recombinant Human Inducible T-cell costimulator is produced by our Mammalian expression system and the target gene encoding Glu21-Phe141 is expressed with a Fc tag at the C-terminus. Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige Protein function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-7878

Properties

Conjugate: No

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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