Recombinant Human Frizzled-7 protein (His tag)

Frizzled-7 is a member of the Frizzled family of unconventional G-protein-coupled glycoprotein receptors for the Wnt signaling pathway . The Wnt genes encode a large family of glycoproteins that are essential in development and tissue maintenance . Like other Frizzled family members, Frizzled-7 contains a divergent N-terminal signal peptide (amino acid (aa) 1-32), a highly conserved extracellular cysteine-rich domain (CRD, aa 44-169), a variable-length linker region (aa 170-256), a seven-pass transmembrane region (aa 257-549), and a variable-length C-terminal cytoplasmic domain (aa 550-574) (1-3). The CRD, which comprises the binding site for Wnts and other ligands such as Syndecan 4 and fibronectin, spans about 130 amino acid residues and contains ten invariant cysteine residue