Recombinant Human Erythropoietin/EPO (C-6His)

Recombinant Human Erythropoietin/EPO (C-6His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-7001-10 10 µg - -

3 - 11 business days*

426.00€
ABE-32-7001-50 50 µg - -

3 - 11 business days*

635.00€
 
Source: Human Cells. MW:19.2kD. Recombinant Human Erythropoietin is produced by our Mammalian... more
Product information "Recombinant Human Erythropoietin/EPO (C-6His)"
Source: Human Cells. MW:19.2kD. Recombinant Human Erythropoietin is produced by our Mammalian expression system and the target gene encoding Ala28-Arg193 is expressed with a 6His tag at the C-terminus. Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Protein function: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-7001

Properties

Conjugate: No

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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