Rat CD40/TNFRSF5 Protein

Recombinant Rat CD40/TNFRSF5 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Val24-Arg193. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.