Prostaglandin D Synthase Protein (His Tag) (recombinant human)

Prostaglandin D Synthase Protein (His Tag) (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH032006.20 20 µg - -

7 - 16 business days*

399.00€
E-PKSH032006.100 100 µg - -

7 - 16 business days*

934.00€
 
Protein Construction: A DNA sequence encoding the human PTGDS (P41222) (Met1-Gln190) was... more
Product information "Prostaglandin D Synthase Protein (His Tag) (recombinant human)"
Protein Construction: A DNA sequence encoding the human PTGDS (P41222) (Met1-Gln190) was expressed with a polyhistidine tag at the C-terminus. Sequence: Met 1-Gln190. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method. Apparent Molecular Mass: 28 kDa. Protein function: PTGDS, also known as L-PGDS, belongs to the calycin superfamily,lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Protein function: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. [The UniProt Consortium]
Keywords: PDS, PGDS, PTGDS, PGDS2, EC=5.3.99.2, Cerebrin-28, PGD2 synthase, Beta-trace protein, Prostaglandin-D2 synthase, Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Recombinant Human Prostaglandin D
Supplier: Elabscience
Supplier-Nr: E-PKSH032006

Properties

Conjugate: No
Expressed in: Human cells
Origin: Human
MW: 20.1 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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