Prion Protein 2 (human recombinant)

Source : Escherichia Coli. PRND Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 149 amino acids (27-152a.a) and having a molecular mass of 58.5kDa. PRND is fused to a 23 amino acid His-tag at N-terminus , purified by proprietary chromatographic techniques. PRND is a membrane glycosylphosphatidylinositol-anchored glycoprotein which exists mainly in testis. PRND is expressed during embryogenesis, although in the central nervous system it is expressed minimally .Mutations in PRND may cause neurological disorders. PRND located on chromosome 20, about 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally analogous. Protein function: Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+) (PubMed:15218028, PubMed:20411530). [The UniProt Consortium]