Nicotinamide N-Methyltransferase (human, recombinant)

Nicotinamide N-Methyltransferase (human, recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15138-100 100 µg -

6 - 10 business days*

642.00€
 
Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing... more
Product information "Nicotinamide N-Methyltransferase (human, recombinant)"
Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds. NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties. The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA. Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.Synonyms: NNMT. Purity: >95% estimated by SDS-PAGE. Source: Recombinant N-terminal His- and SUMO-tagged protein expressed in E. coli. Amino Acids: 2-264 (full length). MW: 42.6 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, containing 500 mM sodium chloride, 5% glycerol, and 1 mM DTT. License: SUMOpro tag was used under non-exclusive license from LifeSensors, Inc.. UniProt Accession #: P40261.
Keywords: NNMT, Nicotinamide N-methyltransferase, Nicotinamide N-methyltransferase
Supplier: Cayman Chemical
Supplier-Nr: 15138

Properties

Application: Enzyme activity
Conjugate: No
Purity: >95% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H316, H319
P Phrases: P264, P280, P305+351+338, P332+313, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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