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Recombinant protein. Human TRIM21 (aa 1-475) is fused at the N-terminus to a Lipoyl domain... more
Product information "Lipoyl-TRIM21 (human) (rec.) (His)"
Recombinant protein. Human TRIM21 (aa 1-475) is fused at the N-terminus to a Lipoyl domain (bacterial pyruvate dehydrogenase) and at the C-terminus to a 6xHis-tag. Source/Host: E. coli. Purity: >90% (SDS-PAGE). Lyophilized. Contains 50mM Tris-HCl, pH 8 and 300mM NaCl. TRIM21 (tripartite motif-containing protein 21) is a cytosolic Fc receptor induced by interferon (IFN). TRIM21 is distinguished from other Fc receptors by showing broad antibody specificity as it can activate its functions upon binding to IgG, IgM as well as IgA while other Fc receptors display more restricted antibody isotype and subtype specificities. TRIM21 also functions as a E3 ligase. During infection, antibodies are delivered efficiently to the cytosol when bound to intracellular pathogens such as viruses and bacteria. The antibody-pathogen complex in the cytosol upon engagement of the protein TRIM21 is ubiquitinylated and degraded by the proteasome machinery. Trim-Away is a method to degrade endogenous proteins based on TRIM21, Fc receptor binding and ubiquitin ligase activity. TRIM21, which recognizes antibody-bound proteins of interest, targets them for degradation by the proteasome. The Lipoyl-TRIM21 (human) (His) (rec.) protein is used in the original papers describing Trim-Away.
Keywords: | E3 Ubiquitin-protein Ligase TRIM21, 52 kDa Ro Protein, Tripartite Motif-containing Protein 21 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40B-0182 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 68 kD |
Purity: | >90% (SDS-PAGE) |
Format: | Solid |
Database Information
KEGG ID : | K10651 | Matching products |
UniProt ID : | P19474 | Matching products |
Gene ID | GeneID 6737 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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