L3MBTL1 MBT domains (human recombinant, GST-tagged)

L3MBTL1 MBT domains (human recombinant, GST-tagged)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14775-100 100 µg -

1 - 10 business days

Key Features Cayman's L3MBTL1 MBT Domains TR-FRET Assay Kit (Cay-601030) was developed using... more
Product information "L3MBTL1 MBT domains (human recombinant, GST-tagged)"
Key Features Cayman's L3MBTL1 MBT Domains TR-FRET Assay Kit (Cay-601030) was developed using L3MBTL1 MBT domains (human recombinant, GST-tagged) protein.Bulk sizes available upon request "The malignant brain tumor (MBT) domain is structurally related to chromatin binding domains, such as chromodomains, tudor domains, and PWWP-domains. MBT domain-containing proteins have a variable number of MBT repeats. The MBT domains recognize methylated lysines on histone tails with varying degree of specificity for the various methyl marks. L3MBTL1, a human homolog of the Drosophila lethal(3)MBT protein, is a member of the polycomb group (PcG) of proteins that functions as a transcriptional repressor. L3MBTL1 contains three MBT repeat domains which collectively bind to either histone H3 or H4. The second and third MBT domains were found to bind preferentially to mono- and dimethylated lysines of histone H3 at lysine 4 (H3K4me1) and histone H4 at lysine 20 (H4K20me2). Recognition of methyl-lysine marks by MBT domains leads to chromatin compaction and a repressed transcriptional state. Further, L3MBTL1 has a tumor suppressor function and is thought to play a role in maintaining genomic stability and DNA replication. This protein product contains the MBT repeat region of L3MBTL1."
Keywords: L3MBTL1, KIAA0681, H-l(3)mbt, L(3)mbt-like, H-l(3)mbt protein, L(3)mbt protein homolog, Lethal(3)malignant brain tumor-like protein 1
Supplier: Cayman Chemical
Supplier-Nr: 14775-100


Application: Binding assays
Expressed in: E.coli
Purity: >90% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H319, H372
P Phrases: P260, P264, P270, P280, P314, P305+P351+P338, P332+P313, P337+P313, P501
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