IL-12 Receptor Subunit Beta1/IL-12RB1/CD212 (C-6His) (recombinant human)

IL-12 Receptor Subunit Beta1/IL-12RB1/CD212 (C-6His) (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH033842.10 10 µg -

7 - 16 business days*

107.00€
E-PKSH033842.50 50 µg -

7 - 16 business days*

321.00€
 
Protein Construction: Recombinant Human Interleukin-12 Receptor Subunit Beta-1 is produced by our... more
Product information "IL-12 Receptor Subunit Beta1/IL-12RB1/CD212 (C-6His) (recombinant human)"
Protein Construction: Recombinant Human Interleukin-12 Receptor Subunit Beta-1 is produced by our Mammalian expression system and the target gene encoding Cys24-Glu540 is expressed with a 6His tag at the C-terminus. Sequence: Cys24-Glu540. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 80-110 kDa. Protein function: Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells. Protein function: Functions as an interleukin receptor which binds interleukin- 12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. [The UniProt Consortium]
Keywords: IL12R, CD212, IL12RB1, IL-12RB1, IL-12R-beta-1, IL-12R subunit beta-1, IL-12 receptor beta component, IL-12 receptor subunit beta-1, Interleukin-12 receptor subunit beta-1, Recombinant Human IL-12 Receptor Subunit Beta1/IL-12RB1/CD212 (C-6His)
Supplier: Elabscience
Supplier-Nr: E-PKSH033842

Properties

Conjugate: No
Host: Human cells
Species reactivity: human
MW: 58.1 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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