Human Fibrinogen (PAD4 Citrullinated)

Human Fibrinogen (PAD4 Citrullinated)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay400076-1 1 mg -

1 - 10 business days

407.00€
 
Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (alpha,... more
Product information "Human Fibrinogen (PAD4 Citrullinated)"
Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (alpha, beta and gamma). Under chronic inflammatory conditions, fibrinogen can be acted upon by the enzyme peptidylarginine deiminase 4 (PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen. The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages. Recently, it has been discovered that immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.
Keywords: cFBG, FGA, Fibrinopeptide A, Fibrinogen alpha chain, FGB, Fibrinopeptide B, Fibrinogen beta chain, FGG, PRO2061, Fibrinogen gamma chain, Citrullination
Supplier-Nr: 400076-1

Properties

Application: WB
Format: Solid

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H319, H332
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P337+P313, P361+P364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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