HSD17B8, Recombinant, Human, aa1-261, His-tag (FABGL, HKE6, RING2)

HSD17B8, Recombinant, Human, aa1-261, His-tag (FABGL, HKE6, RING2)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
H9117-83U.100 100 µg - -

1 - 19 business days

519.00€
 
HSD17B8, also known as estradiol 17-beta-dehydrogenase 8, belongs to the short-chain... more
Product information "HSD17B8, Recombinant, Human, aa1-261, His-tag (FABGL, HKE6, RING2)"
HSD17B8, also known as estradiol 17-beta-dehydrogenase 8, belongs to the short-chain dehydrogenases/reductases (SDR) family. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. It may play a role in biosynthesis of fatty acids in mitochondria. Source: Recombinant corresponding to aa1-261 from human HSD17B8, fused to His-tag at N-terminus expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK, VGNVGQTNYA ASKAGVIGLT QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL ASEDSGYITG TSVEVTGGLF M, Molecular Weight: ~29.1kD (281aa), confirmed by MALDI-TOF , Enzyme Activity: Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Ke-6, EC=1.1.1.-, Protein Ke6, EC=1.1.1.63, EC=1.1.1.62, 17-beta-HSD 8, Estradiol 17-beta-dehydrogenase 8, Testosterone 17-beta-dehydrogenase 8, Really interesting new gene 2 protein, 17-beta-hydroxysteroid dehydrogenase 8
Supplier: United States Biological
Supplier-Nr: H9117-83U

Properties

Conjugate: No
MW: 29,1 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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