GDP-L-Fucose Synthase (human, recombinant)

GDP-L-Fucose Synthase (human, recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay26695-100 100 µg -

6 - 10 business days*

642.00€
 
GDP-L-Fucose synthase, encoded by the gene TSTA3, is an NADP(H)-binding protein that catalyzes... more
Product information "GDP-L-Fucose Synthase (human, recombinant)"
GDP-L-Fucose synthase, encoded by the gene TSTA3, is an NADP(H)-binding protein that catalyzes the final step in the synthesis of GDP-L-fucose from GDP-D-mannose. It converts GDP-4-keto-6-deoxy-D-mannose to GDP-L-fucose via a two-step reaction consisting of epimerization followed by NADPH-dependent reduction. GDP-L-Fucose synthase exists as a homodimer and is comprised of an N-terminal NADPH-binding domain and a C-terminal substrate-binding domain. TSTA3-/- mice exhibit increases in colonic inflammation, dysplasia, and epithelial permeability, which are reversed following addition of fucose to the diet. These mice also exhibit alterations in gut microflora and increased bacterial burden in colon transluminal tissue and feces when fed a normal diet versus a fucose-supplemented diet, and the colonic effects of TSTA3 deletion can be reversed following administration of antibiotics. GDP-L-Fucose synthase has been identified as an autoantigen that can be recognized by CD4+ T cells derived from patients with multiple sclerosis. Expression of GDP-L-fucose synthase in primary tumor tissue samples from patients with esophageal squamous cell carcinoma (ESCC) positively correlates with increased clinical stage, lymph node metastasis, and poor prognosis.Synonyms: GDP-4-keto-6-deoxy-D-Mannose-3,5-Epimerase-4-Reductase, Protein FX, Red Cell NADP(H)-Binding Protein, Short-Chain Dehydrogenase/Reductase Family 4E Member 1, Tissue Specific Transplantation Antigen P35B, TSTA3. Purity: >90% estimated by SDS-PAGE. Source: Recombinant N-terminal histidine-tagged GDP-L-fucose synthase purified from E. coli. Amino Acids: 2-321. MW: 37.98 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol. UniProt Accession #: Q13630.
Keywords: SDR4E1, Protein FX, Protein FX, GDP-L-fucose synthase, GDP-L-fucose synthase, Red cell NADP(H)-binding protein, Red cell NADP(H)-binding protein, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, Short-chain dehydrogenase/reductase family 4E member
Supplier: Cayman Chemical
Supplier-Nr: 26695

Properties

Application: WB
Conjugate: No
Purity: >90% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "GDP-L-Fucose Synthase (human, recombinant)"
Write a review
or to review a product.
Viewed