Gankyrin/PSDM10 Protein (recombinant human)

Gankyrin/PSDM10 Protein (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH032479.10 10 µg -

7 - 16 business days*

327.00€
E-PKSH032479.50 50 µg -

7 - 16 business days*

624.00€
 
Protein Construction: Recombinant Human Gankyrin is produced by our E.coli expression system and... more
Product information "Gankyrin/PSDM10 Protein (recombinant human)"
Protein Construction: Recombinant Human Gankyrin is produced by our E.coli expression system and the target gene encoding Met1-Gly226 is expressed. Sequence: Met 1-Gly226. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 26 kDa. Protein function: Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis. Protein function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. [The UniProt Consortium]
Keywords: PSMD10, Gankyrin, p28(GANK), 26S proteasome regulatory subunit p28, 26S proteasome non-ATPase regulatory subunit 10, Recombinant Human Gankyrin/PSDM10 Protein
Supplier: Elabscience
Supplier-Nr: E-PKSH032479

Properties

Conjugate: No
Host: E.coli
Species reactivity: human
MW: 244 kD
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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