Galectin-4, His tag, mouse recombinant (rmLGALS4-His)

Galectin-4, His tag, mouse recombinant (rmLGALS4-His)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97606.2 2 µg - -

3 - 10 business days*

70.00€
97606.10 10 µg - -

3 - 10 business days*

180.00€
97606.1 1 mg - -

3 - 10 business days*

-
 
LGALS4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain... more
Product information "Galectin-4, His tag, mouse recombinant (rmLGALS4-His)"
LGALS4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (1-326a.a) and having a molecular mass of 31.8kDa.LGALS4 is fused to a 23 amino acid His-tag at N-terminus. Galectin-4 is a member of the subfamily of galectins composed of two carbohydrate recognition domains having similar peptide chains. The galectins are a family of beta-galactoside-binding proteins having a role in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic responses. LGALS4 expression is limited to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. LGALS4 binds as an endogenous ligand to glycosphingolipids having 3-O-sulfated Gal residues and bind as well to cholesterol-3-sulfate. LGALS4 takes part in cell adhesion. LGALS4 plays a role in crosslinking the lateral cell membranes of the surface-lining epithelial cells, thus supporting epithelial integrity against mechanical stress exerted by the bowel lume. LGALS4 is in charge of intestinal inflammation via selective regulation of peripheral and mucosal T-cell cell cycle, in addition to cell death by apoptosis of T-cells by a pathway independent of the activation of caspases. LGALS4 blockade decreases TNF-alpha inhibitor induced T-cell death. LGALS4 decreases pro-inflammatory cytokine secretion including IL-6 and IL-17.
Keywords: Gal-4, Lgals4, Galectin-4, Lactose-binding lectin 4
Supplier: Biomol GmbH
Supplier-Nr: 97606

Properties

Application: Bioassays
Conjugate: No
Expressed in: E.coli
Origin: Mouse
MW: 31800 D
Purity: >90%
Format: Solution

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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