Fatty Acid Desaturase 1 (human recombinant)

Fatty acid desaturase 1 (FADS1), also known as Delta5 desaturase, is a 444-amino acid transmembrane protein encoded by FADS1. This product is the N-terminal cytoplasmic domain of FADS1, corresponding to residues 2-121 of the full-length sequence. It catalyzes conversion of dihomo-gamma-linolenic acid (Cay-90230) to arachidonic acid (Cay-90010) and omega-3 arachidonic acid (Cay-90011) to eicosapentaenoic acid (Cay-90110, Cay-90110.1, Cay-21908) during the production of omega-6 and omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), respectively. Hepatic FADS1 protein levels and mRNA expression are increased in mice with high-fat diet-induced obesity and non-alcoholic steatohepatitis (NASH). Tissue-selective knockdown of fads1 in the liver, adipose tissue, and reticuloendothelial system of adult hyperlipidemic LDL receptor-null mice promotes hepatic inflammation and formation of atherosclerotic plaques and suppresses hepatic lipogenesis. Increased expression of FADS1 positively correlates with disease-free survival and overall survival times in patients with esophageal squamous cell carcinoma (ESCC).Synonyms: Acyl-CoA (8-3)-Desaturase, Delta5 Desaturase, Delta5D, Delta5 Desaturase, EC 1.14.19., FADS1, FADSDelta5, FADS6, Delta5 Fatty Acid Desaturase, Linoleoyl-CoA Desaturase (Delta6 Desaturase)-Like 1, TU12. Purity: >80% estimated by SDS-PAGE. Source: Recombinant N-terminal His-tagged FADS1 N-terminal domain purified from E. coli. Amino Acids: 2-121. MW: 15.89 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol. UniProt Accession #: O60427.