DAG1 Recombinant Protein

DAG1 Recombinant Protein
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-3649-10 10 µg - -

3 - 11 business days*

468.00€
 
Source : Escherichia Coli. DAG1 Human Recombinant produced in E.Coli is a single,... more
Product information "DAG1 Recombinant Protein"
Source : Escherichia Coli. DAG1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 30-312) containing 293 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 31.87kDa (calculated). Dystroglycan 1 (DAG1) is a laminin binding component of the dystrophin-glycoprotein complex which provides a connection between the subsarcolemmal cytoskeleton and the extracellular matrix. The N-terminal domain of alpha-dystroglycan is secreted into the cerebrospinal fluid. The effect of DAG1 on the nervous system remains vague. The complete dystroglycan complex is expressed in a various tissues and has a role in processes such as laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. DAG1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic decrease of DAG1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, making muscle fibers more susceptible to necrosis.
Supplier: Abeomics
Supplier-Nr: 32-3649

Properties

Conjugate: No

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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