Cochlin (human) (LCCL domain) (rec.) MultiPack

Cochlin (human) (LCCL domain) (rec.) MultiPack
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-40B-0135-C010 10 µg -

3 - 9 business days*

341.00€
AG-40B-0135-3010 30 µg (3 x 10 ug) -

3 - 9 business days*

682.00€
 
3 x 10 µg. Human cochlin (LCCL domain) (aa 25-132) is fused at the N-terminus to a FLAG(R)-tag.... more
Product information "Cochlin (human) (LCCL domain) (rec.) MultiPack"
3 x 10 µg. Human cochlin (LCCL domain) (aa 25-132) is fused at the N-terminus to a FLAG(R)-tag. Protein function: Plays a role in the control of cell shape and motility in the trabecular meshwork. [The UniProt Consortium] Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterized by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.
Keywords: COCH, COCH5B2, Cochlin, COCH-5B2
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40B-0135

Properties

Conjugate: No
Expressed in: Human cells
Origin: Human
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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