Citrullinated Histone H3 (human, recombinant)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17926-100 100 µg -

6 - 10 business days*

730.00€
 
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for... more
Product information "Citrullinated Histone H3 (human, recombinant)"
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications, including citrullination. Histone H3 is subject to citrullination of arginine residues by peptidyl arginine deiminase 4 (PAD4) at positions 2, 8, 17, and 26, and this citrullination blocks methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and induces transcriptional repression of target genes. Citrullinated histone H3 is a component of neutrophil extracellular traps (NETs) that acts as an autoantigen to induce the production of anti-citrullinated protein antibodies associated with various diseases such as sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma. Cayman's Citrullinated Histone H3 (human, recombinant) protein is derived from purified Histone H3 (human, recombinant) (Cay-10263) that has been modified by PAD4, which is removed by affinity chromatography after the reaction.Synonyms: H3, H3C1, Histone H3.1. Purity: >95% estimated by SDS-PAGE. Protein Identity Confirmed by Mass Spec: Yes. Source: Recombinant human histone H3 expressed in E. coli and citrullinated by PAD4. Amino Acids: 1-136 (full length). MW: 15.5 kDa. Formulation: (Request formulation change), A solution in PBS, pH 7.4. Host: E. coli. Applications: Immunoreactive with anti-citrulline antibodies by Western blot and ELISA. UniProt Accession #: P68431.
Keywords: H3FA, H3FL, H3FB, H3FD, H3FI, H3FH, H3FK, H3FF, H3FJ, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, Histone H3.1, Histone H3/a, Histone H3/b, Histo
Supplier: Cayman Chemical
Supplier-Nr: 17926

Properties

Application: ELISA, WB
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 15.5 kD
Purity: >95% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Citrullinated Histone H3 (human, recombinant)"
Write a review
or to review a product.
Viewed