CD278 [ICOS] (human): Fc (human) (rec.)

CD278 [ICOS] (human): Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-210ICOS-C025 25 µg - -

3 - 9 business days*

176.00€
CHI-HF-210ICOS-C100 100 µg - -

3 - 9 business days*

374.00€
 
Unfortunately, most cytokines and related proteins have short circulating half-lives. With the... more
Product information "CD278 [ICOS] (human): Fc (human) (rec.)"
Unfortunately, most cytokines and related proteins have short circulating half-lives. With the creation of a group of new immunoglobulin- based cytokine fusion proteins, in which a cytokine sequence had been genetically fused to the hinge, CH2 and CH3 regions of an immunoglobulin, these cytokine fusion proteins possess both the biological functions of the cytokine moiety and the prolonged circulating half-life determined by the Fc domain. CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Keywords: ICOS, CD278, AILIM, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-210ICOS

Properties

Application: Bioassays
Conjugate: No
Expressed in: Hamster cells
Origin: Human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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