CD276 [B7-H3] (mouse):Fc (mouse) (rec.) (non-lytic)

CD276 [B7-H3] (mouse):Fc (mouse) (rec.) (non-lytic)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-MF-120B7H3-C100 100 µg - -

3 - 9 business days*

484.00€
 
Recombinant Protein. The extracellular domain of mouse CD276 [B7-H3] (aa 30-248) is fused to the... more
Product information "CD276 [B7-H3] (mouse):Fc (mouse) (rec.) (non-lytic)"
Recombinant Protein. The extracellular domain of mouse CD276 [B7-H3] (aa 30-248) is fused to the N-terminus of the Fc region of mutant mouse IgG2a. Source/Host: HEK 293 cells. Endotoxin: <0.001EU/µg protein (LAL test, Lonza). Lyophilized from 0.2µm-filtered solution in PBS. CD276 (B7-H3) is a member of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T cell response. B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are known to modulate T cell receptor (TCR)-mediated T cell activation by providing co-signals that are either stimulatory or inhibitory. B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3 is a negative regulator that preferentially affects T(H)1 responses. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. Recently, B7-H3 expression has also been found in a variety of different human cancers, including prostate cancer, clear cell renal cell carcinoma (ccRCC), non-small-cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, ovarian cancer, colorectal cancer (CRC) and urothelial cell carcinoma. B7-H3 was expressed in some human cancers and correlated with poor outcome of cancer patients.
Keywords: B7h3, Cd276, CD276, B7-H3, B7 homolog 3, CD276 antigen, Costimulatory molecule
Supplier: Chimerigen Laboratories
Supplier-Nr: MF-120B7H3

Properties

Conjugate: No
Host: Human cells
Purity: >98% (SDS-PAGE)
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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