CBX3 (human recombinant)

CBX3 (human recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15467-100 100 µg -

6 - 10 business days*

465.00€
 
The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-alpha (CBX5), HP1-beta... more
Product information "CBX3 (human recombinant)"
The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-alpha (CBX5), HP1-beta (CBX1), and HP1-gamma (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation. CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain that connects the two. Extensive post-translational modifications have been observed and mapped on the CBX proteins. The chromodomain of CBX3 has been shown to recognize methylated histone H3 lysine 9, methylated histone H1 lysine 26, and G9A methylated at lysine 185. CBX3 associates with the exons of a subset of actively transcribed genes, and loss of CBX3 results in accumulation of unspliced mRNA from that subset of genes. Further, CBX3 suppresses Nanog gene transcription in pre-induced pluripotent stem cells and long terminal repeat protein expression in HIV-1 infected cells. Knockdown of CBX3 by siRNA in cells latently infected with HIV-1 leads to virus reactivation. CBX3 has been proposed to be a biomarker for tumor stem cells in osteosarcoma.Synonyms: Chromobox Protein Homolog 3, Heterochromatin Protein 1 Homolog gamma, HP1-gamma. Purity: >95% (estimated by SDS-PAGE). Source: Recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 2-183 (full length). MW: 48.4 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 7.4, containing 150 mM sodium chloride and 20% glycerol. UniProt Accession #: Q13185.
Keywords: CBX3, HECH, HECH, HP1 gamma, HP1 gamma, Modifier 2 protein, Modifier 2 protein, Chromobox protein homolog 3, Chromobox protein homolog 3, Heterochromatin protein 1 homolog gamma, Heterochromatin protein 1 homolog gamma
Supplier: Cayman Chemical
Supplier-Nr: 15467

Properties

Application: Binding assays
Conjugate: No
Host: E.coli
Species reactivity: human
Purity: >95% (estimated by SDS-PAGE)
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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