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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH033846.10 | 10 µg | - |
7 - 16 business days* |
111.00€
|
|||
E-PKSH033846.50 | 50 µg | - |
7 - 16 business days* |
329.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Human Angiopoietin Like Protein 4 is produced by our Mammalian... more
Product information "Angiopoietin-Related Protein 4/ANGPTL4 (N-6His) (recombinant human)"
Protein Construction: Recombinant Human Angiopoietin Like Protein 4 is produced by our Mammalian expression system and the target gene encoding Pro166-Ser406 is expressed with a 6His tag at the N-terminus. Sequence: Pro166-Ser406. Fusion tag: N-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 32-38 kDa. Protein function: Angiopoietin-related protein 4(ANGPTL4)is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. Protein function: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis. [The UniProt Consortium]
Keywords: | ARP4, ANGPTL4, Recombinant Human Angiopoietin-Related Protein 4/ANGPTL4 (N-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH033846 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 27.9 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K08767 | Matching products |
UniProt ID : | Q9BY76 | Matching products |
Gene ID | GeneID 51129 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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