Aldo-Keto Reductase Family 1 Member C4 , Recombinant, Human, aa1-323, His-tag (AKR1C4, HGNC:387, 3-a

Aldo-Keto Reductase Family 1 Member C4 , Recombinant, Human, aa1-323, His-tag (AKR1C4, HGNC:387, 3-a
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A1334-70Z.100 100 µg - -

1 - 19 business days

451.00€
 
AKR1C4 belongs to aldo/keto reductase superfamily, which consists of more than 40 known enzymes... more
Product information "Aldo-Keto Reductase Family 1 Member C4 , Recombinant, Human, aa1-323, His-tag (AKR1C4, HGNC:387, 3-a"
AKR1C4 belongs to aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. It catalyzes the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. Purified by using conventional chromatography. Source: Recombinant corresponding to aa1-323 of human AKR1C4, fused to His-tag at N-terminal, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN RNYRYVVMDF LMDHPDYPFS DEY, Molecular Weight: ~39.2kD (343aa), confirmed by MALDI-TOF, Biological Activity: Specific activity: approximately >0.6units/mg. Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25C. Specific activity was expressed as units/mg protein. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: DD-4, EC=1.1.1.-, EC=1.1.1.50, 3-alpha-HSD1, EC=1.1.1.225, Chlordecone reductase, Dihydrodiol dehydrogenase 4, Aldo-keto reductase family 1 member C4, 3-alpha-hydroxysteroid dehydrogenase type I
Supplier: United States Biological
Supplier-Nr: A1334-70Z

Properties

Conjugate: No
MW: 39,2 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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