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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH030775.100 | 100 µg | - |
7 - 16 business days* |
1,277.00€
|
Protein Construction: A DNA sequence encoding the human ALDH4A1 (AAH07581.1) (Lys 25-Gln 563) was... more
Product information "ALDH4A1 Protein (recombinant human)"
Protein Construction: A DNA sequence encoding the human ALDH4A1 (AAH07581.1) (Lys 25-Gln 563) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus. Sequence: Lys 25-Gln 563. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 54 kDa. Protein function: ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks (amino acids). Additional aldehyde dehydrogenase enzymes detoxify external substances, such as alcohol and pollutants, and internal substances, such as toxins that are formed within cells. ALDH4A1 is expressed abundantly in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. It is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation. Protein function: Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. [The UniProt Consortium]
Keywords: | ALDH4, ALDH4A1, EC=1.2.1.88, P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase, Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, Recombinant Human ALDH4A1 Protein |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH030775 |
Properties
Conjugate: | No |
Host: | Insect cells |
Species reactivity: | human |
MW: | 59.2 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K00294 | Matching products |
UniProt ID : | P30038 | Matching products |
Gene ID | GeneID 8659 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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