Activating Transcription Factor 3 , Recombinant, Human, aa1-181 (ATF3, cAMP-dependent Transcription

Activating Transcription Factor 3 , Recombinant, Human, aa1-181 (ATF3, cAMP-dependent Transcription
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A0855-58J.100 100 µg - -

1 - 19 business days

451.00€
 
ATF3 (activating transcription factor 3) is a member of the mammalian activation transcription... more
Product information "Activating Transcription Factor 3 , Recombinant, Human, aa1-181 (ATF3, cAMP-dependent Transcription"
ATF3 (activating transcription factor 3) is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription, it is presumed, by sequestering inhibitory co-factors away from the promoter. Recombinant protein corresponding to aa1-181 of human ATF3, expressed in E. coli (NP_001665). Amino Acid Sequence: MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S , Molecular Weight: , ~20.6kD (181aa), Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Activating transcription factor 3, cAMP-dependent transcription factor ATF-3, Cyclic AMP-dependent transcription factor ATF-3
Supplier: United States Biological
Supplier-Nr: A0855-58J

Properties

Conjugate: No
MW: 20,6 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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