ACE2 (human):Fc (human) (rec.)

ACE2 (human):Fc (human) (rec.)
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-B232006-C100 100 µg - -

3 - 9 business days*

600.00€
 
Extracellular domain of human ACE2 (aa 1-740) is fused to the N-terminus of the Fc region of... more
Product information "ACE2 (human):Fc (human) (rec.)"
Extracellular domain of human ACE2 (aa 1-740) is fused to the N-terminus of the Fc region of human IgG1. Biological Activity: Binds to the Spike protein of the coronavirus SARS-CoV-2. Endotoxin Content: <0.001EU/µg purified protein (LAL test). Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19. It has been shown that human recombinant soluble ACE2 can significantly block early stages of SARS-CoV-2 infections.
Keywords: ACE2, EC=3.4.17.23, Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, SARS Receptor, SARS-CoV-2 Receptor
Supplier: Chimerigen Laboratories
Supplier-Nr: B232006

Properties

Application: Bindig assays
Conjugate: No
Host: Human cells
Species reactivity: human
Purity: >=90% (SDS-PAGE)
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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