MeO-Suc-RPY-pNA (trifluoroacetate salt)

MeO-Suc-RPY-pNA is a colorimetric substrate for serine proteases, including trypsin, chymotrypsin, kallikrein-related peptidase 7 (KLK7), and kallikrein-related peptidase 3/prostate-specific antigen. Serine proteases preferentially bind to and cleave the Arg-Pro-Tyr (RPY) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of serine protease activity.Formal Name: N2-(4-methoxy-1,4-dioxobutyl)-L-arginyl-L-prolyl-N-(4-nitrophenyl)-L-tyrosinamide, trifluoroacetate salt. Synonyms: Methoxy-Succinyl-Arg-Pro-Tyr-pNA, Methoxy-Succinyl-Arg-Pro-Tyr-p-nitroanilide, Serine Protease Chromogenic Substrate, S 2586. Molecular Formula: C31H40N8O9 . XCF3COOH. Formula Weight: 668.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20mg/mL, DMSO: 3mg/mL, PBS (pH 7.2): 3mg/mL. lambdamax: 225, 316 nm. SMILES: COC(CCC(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](CC2=CC=C(O)C=C2)C(NC3=CC=C([N+]([O-])=O)C=C3)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C31H40N8O9.C2HF3O2/c1-48-27(42)15-14-26(41)36-23(4-2-16-34-31(32)33)30(45)38-17-3-5-25(38)29(44)37-24(18-19-6-12-22(40)13-7-19)28(43)35-20-8-10-21(11-9-20)39(46)47,3-2(4,5)1(6)7/h6-13,23-25,40H,2-5,14-18H2,1H3,(H,35,43)(H,36,41)(H,37,44)(H4,32,33,34),(H,6,7)/t23-,24-,25-,/m0./s1. InChi Key: OSKBXHZCWLGBBY-NAGNLMCHSA-N.