Calpain Inhibitor I

Calpain Inhibitor I
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14921-1 1 mg -

1 - 10 business days

Cay14921-5 5 mg -

1 - 10 business days

Cay14921-10 10 mg -

1 - 10 business days

Cay14921-25 25 mg -

1 - 10 business days

Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of... more
Product information "Calpain Inhibitor I"
Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). At 10-100 µM calpain inhibitor I dose-dependently prevents the degradation of IkappaBalpha and IkappaBbeta by the ubiquitin-proteasome complex, which blocks activation of NFkappaB and the production of TNF and IL-1beta, suggesting a potential therapeutic effect for inflammatory diseases. At 10 µM, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Keywords: Ac-Leu-Leu-Nle-Aldehyde, ALLN, MG 101, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-leucinamide
Supplier: Cayman Chemical
Supplier-Nr: 14921-1


Application: Cysteine protease inhibitor
Conjugate: No
MW: 383.5 D
Formula: C20H37N3O4
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 110044-82-1| Find alternatives
KEGG ID : K01363 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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