Ac-QPKK(Ac)-AMC

Ac-QPKK(Ac)-AMC
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay30790-1 1 mg -

6 - 10 business days*

98.00€
Cay30790-5 5 mg -

6 - 10 business days*

434.00€
Cay30790-10 10 mg -

6 - 10 business days*

770.00€
Cay30790-25 25 mg -

6 - 10 business days*

1,556.00€
 
Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3. It is... more
Product information "Ac-QPKK(Ac)-AMC"
Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3. It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.Formal Name: N2-acetyl-L-glutaminyl-L-prolyl-L-lysyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide. CAS Number: 1387005-23-3. Synonyms: Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, p53317-320 Substrate (Ac-QPKK(Ac)-AMC). Molecular Formula: C36H52N8O9. Formula Weight: 740.9. Purity: >98%. Emission: 440-460 nm. Excitation: 340-360 nm. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/mL, DMSO: 15 mg/mL, Ethanol: Slightly Soluble, PBS (pH 7.2): 10 mg/mL. SMILES: NCCCC[C@@H](C(N[C@H](C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)CCCCNC(C)=O)=O)NC([C@@H]3CCCN3C([C@H](CCC(N)=O)NC(C)=O)=O)=O. InChi Code: InChI=1S/C36H52N8O9/c1-21-19-32(48)53-30-20-24(12-13-25(21)30)41-33(49)26(10-5-7-17-39-22(2)45)42-34(50)27(9-4-6-16-37)43-35(51)29-11-8-18-44(29)36(52)28(40-23(3)46)14-15-31(38)47/h12-13,19-20,26-29H,4-11,14-18,37H2,1-3H3,(H2,38,47)(H,39,45)(H,40,46)(H,41,49)(H,42,50)(H,43,51)/t26-,27-,28-,29-/m0/s1. InChi Key: LHVYYJGFOAKRPP-DZUOILHNSA-N.
Keywords: Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, p53317-320 Substrate (Ac-QPKK(Ac)-AMC), N2-acetyl-L-glutaminyl-L-prolyl-L-lysyl-N6-acetyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
Supplier: Cayman Chemical
Supplier-Nr: 30790

Properties

Application: Fluorogenic SIRT1 substrate
Conjugate: No
MW: 740.9 D
Formula: C36H52N8O9
Purity: >98%
Format: Solid

Database Information

CAS : 1387005-23-3| Matching products
KEGG ID : K11411 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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