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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24747-500 | 500 µg | - |
6 - 10 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF)... more
Product information "Urocortin II (mouse) (trifluoroacetate salt)"
Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin (Cay-24744), urocortin III (Cay-24748, Cay-24749, Cay-24750), frog sauvagine, and piscine urotensin I. Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin (Cay-24745). It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF1 over CRF2 receptors (Kis = 0.66 and >100 nM, respectively) and induces cAMP production in CHO cells expressing CRF2 (EC50 = 0.14 nM). In vivo, urocortin II suppresses nighttime food intake by 35% in rats when administered intracerebroventricularly at a dose of 1 µg. Urocortin II (0.1 and 0.5 µg, i.c.v) stimulates fecal pellet output, increases distal colonic transit, and inhibits gastric emptying in mice.Formal Name: L-valyl-L-isoleucyl-L-leucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-arginyl-L-isoleucyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-tyrosyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-asparaginyl-L-glutaminyl-L-alanyl-L-alanyl-L-threonyl-L-asparaginyl-L-alanyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-alanyl-L-histidyl-L-valinamide, trifluoroacetate salt. Molecular Formula: C187H320N56O50 . XCF3COOH. Formula Weight: 4152.9. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@@]([C@H](CC)C)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](C(C)C)N[H])=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC2=CC=C(O)C=C2)=O)=O)C)=O)C)=O)=O)=O)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)CC3=CN=CN3)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C187H320N56O50.C2HF3O2/c1-37-95(25)143(240-177(286)131-51-46-68-243(131)184(293)142(94(23)24)237-175(284)129(80-139(255)256)230-169(278)122(73-89(13)14)227-176(285)130(83-244)235-171(280)124(75-91(17)18)233-182(291)146(98(28)40-4)241-178(287)140(194)92(19)20)179(288)206-82-137(252)215-118(69-85(5)6)166(275)225-120(71-87(9)10)167(276)220-113(50-45-67-205-187(200)201)162(271)238-144(96(26)38-2)181(290)232-123(74-90(15)16)170(279)226-121(72-88(11)12)168(277)223-117(59-63-138(253)254)161(270)221-114(56-60-132(189)247)157(266)212-102(32)152(261)217-111(48-43-65-203-185(196)197)159(268)228-125(76-107-52-54-109(246)55-53-107)172(281)219-110(47-41-42-64-188)156(265)210-99(29)149(258)208-101(31)151(260)216-112(49-44-66-204-186(198)199)160(269)229-128(79-136(193)251)173(282)222-115(57-61-133(190)248)158(267)211-100(30)150(259)209-105(35)155(264)242-147(106(36)245)183(292)234-127(78-135(192)250)165(274)214-103(33)153(262)218-116(58-62-134(191)249)163(272)239-145(97(27)39-3)180(289)231-119(70-86(7)8)164(273)213-104(34)154(263)224-126(77-108-81-202-84-207-108)174(283)236-141(93(21)22)148(195)257,3-2(4,5)1(6)7/h52-55,81,84-106,110-131,140-147,244-246H,37-51,56-80,82-83,188,194H2,1-36H3,(H2,189,247)(H2,190,248)(H2,191,249)(H2,192,250)(H2,193,251)(H2,195,257)(H,202,207)(H,206,288)(H,208,258)(H,209,259)(H,210,265)(H,211,267)(H,212,266)(H,213,273)(H,214,274)(H,215,252)(H,216,260)(H,217,261)(H,218,262)(H,219,281)(H,220,276)(H,221,270)(H,222,282)(H,223,277)(H,224,263)(H,225,275)(H,226,279)(H,227,285)(H,228,268)(H,229,269)(H,230,278)(H,231,289)(H,232,290)(H,233,291)(H,234,292)(H,235,280)(H,236,283)(H,237,284)(H,238,271)(H,239,272)(H,240,286)(H,241,287)(H,242,264)(H,253,254)(H,255,256)(H4,196,197,203)(H4,198,199,204)(H4,200,201,205),(H,6,7)/t95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,140-,141-,142-,143-,144-,145-,146-,147-,/m0./s1. InChi Key: OREOSNBCOKCDTJ-FWBCUHGPSA-N.
Keywords: | L-valyl-L-isoleucyl-L-leucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-arginyl-L-isoleucyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-tyrosyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-as |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24747 |
Properties
Application: | Neuropeptide hormone |
Conjugate: | No |
MW: | 4152.9 D |
Formula: | C187H320N56O50 . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
KEGG ID : | K05257 | Matching products |
UniProt ID : | Q99ML8 | Matching products |
Gene ID | GeneID 171530 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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