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Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to... more
Product information "Triptorelin (trifluoroacetate salt)"
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor (GnRHR, Ki = 0.3 nM in CHO cells expressing the human receptor). It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells (IC50s = 62.1, 73.4, 98.1, and 67.7 µM, respectively). Triptorelin also inhibits the growth of the triple-negative breast cancer (TNBC) cell lines HCC1806 and MDA-MB-231 (EC50s = 58.29 and 31.59 µM, respectively). It stimulates follicle stimulating hormone (FSH) and luteinizing hormone (LH) release from primary rat pituitary cells when used at a concentration of 50 nM. It also decreases tumor volume of Dunning R3327H prostate tumor flank implants and reduces prostate and testis weight in rats when administered at a dose of 1 mg/kg per day. Formulations containing triptorelin have been used in the palliative treatment of advanced prostate cancer.Formal Name: 6-D-tryptophan-luteinizing hormone-releasing factor (swine), trifluoroacetate. CAS Number: 2240176-35-4. Synonyms: [D-Trp6]-GnRH, [D-Trp6]LH-RH, AY 25650, BIM 21003, CL 118,53, Wy 42422, Wy 42462. Molecular Formula: C64H82N18O13 . XCF3COOH. Formula Weight: 1311.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 3mg/mL, PBS (pH 7.2): 3mg/mL. lambdamax: 222 nm. SMILES: O=C([C@@H]1CCC(N1)=O)N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](CC6=CNC7=CC=CC=C67)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N8CCC[C@H]8C(NCC(N)=O)=O)=O=C([C@@H]1CCC(N1)=O)N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](CC6=CNC7=CC=CC=C67)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N8CCC[C@H]8C(NCC(N)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C64H82N18O13.C2HF3O2/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44,3-2(4,5)1(6)7/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69),(H,6,7)/t44-,45-,46-,47-,48+,49-,50-,51-,52-,/m0./s1. InChi Key: KHNZXCLOURPVAS-OYLNGHKZSA-N.
Keywords: | AY 25650, [D-Trp6]-GnRH, [D-Trp6]LH-RH, BIM 21003, CL 118,53, Wy 42422, Wy 42462, 6-D-tryptophan-luteinizing hormone-releasing factor (swine) |
Supplier: | Cayman Chemical |
Supplier-Nr: | 28613 |
Properties
Application: | Gonadotropin-releasing hormone receptor agonist |
Conjugate: | No |
MW: | 1311.4 D |
Formula: | C64H82N18O13 . XCF3COOH |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 2240176-35-4| Matching products |
KEGG ID : | K04280 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H360 |
P Phrases: | P201, P202, P280, P308+313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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