Thymulin (acetate hydrate)

Thymulin is a zinc-dependent metallopeptide hormone with immunomodulatory, anti-inflammatory, and analgesic activities. It is primarily produced by thymic epithelial cells but can be produced by macrophages and fibroblasts when exposed to extracellular stressors, such as heat or oxidative stress. Thymulin potentiates mitogen-induced proliferation of IL-2 receptor-positive mature T cells. It reduces pro-inflammatory cytokine production in rodent models of LPS- or endotoxin-induced systemic inflammation, as well as prevents myocardial inflammation in a mouse model of encephalomyocarditis virus-induced myocarditis and suppresses autoantibody production in a mouse model of reovirus-induced thyroiditis. Thymulin (0.1, 0.5, and 1 µg, i.c.v.) prevents endotoxin-induced hyperalgesia in rats.Formal Name: 5-oxo-L-prolyl-L-alanyl-L-lysyl-L-seryl-L-glutaminylglycylglycyl-L-seryl-L-asparagine, acetate, hydrate. Synonyms: Thymic Factor. Molecular Formula: C33H54N12O15 . XC2H4O2 [XH2O]. Formula Weight: 858.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: slightly soluble, PBS (pH 7.2): 10 mg/ml. SMILES: NC(C[C@@H](C(O)=O)NC([C@H](CO)NC(CNC(CNC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](C)NC([C@@H]1CCC(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O.O. InChi Code: InChI=1S/C33H54N12O15.C2H4O2.H2O/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49,1-2(3)4,/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60),1H3,(H,3,4),1H2/t15-,16-,17-,18-,19-,20-,21-,,/m0../s1. InChi Key: JQVNJWHUPXMDCN-FDZYDGOCSA-N.