Thiostrepton

Thiostrepton
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay19200-500 500 mg -

6 - 10 business days*

88.00€
Cay19200-1 1 g -

6 - 10 business days*

129.00€
Cay19200-5 5 g -

6 - 10 business days*

551.00€
 
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with... more
Product information "Thiostrepton"
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.Formal Name: N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide, (1->528)-lactone. CAS Number: 1393-48-2. Synonyms: Bryamycin, NSC 81722, NSC 170365, Thiactin, Thiostreptin A. Molecular Formula: C72H85N19O18S5. Formula Weight: 1664.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 1 mg/ml. SMILES: O=C([C@@H](NC(C(NC([C@@H](NC([C@@H](N[C@H](C=C1)[C@]2([H])O)[C@@H](C)CC)=O)C)=O)=C)=O)C)N[C@](C3=NC(C(N[C@H](C(N/C(C4=N[C@]5([H])CS4)=C\C)=O)[C@H](O)C)=O)=CS3)(CCC(C6=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS6)=N7)[C@@]7([H])C8=CSC([C@@]([C@H](OC(C9=CC([C@@H](O)C)=C1C2=N9)=O)C)([H])NC(C%10=CSC([C@](NC5=O)([H])[C@](C)(O)[C@H](O)C)=N%10)=O)=N8. InChi Code: InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)5. InChi Key: NSFFHOGKXHRQEW-AIHSUZKVSA-N. Origin: Bacterium/Streptomyces laurentii.
Keywords: Bryamycin, NSC 170365, NSC 81722, Thiactin, Thiostreptin A, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihyd
Supplier: Cayman Chemical
Supplier-Nr: 19200

Properties

Application: FoxM1 inhibitor
Conjugate: No
MW: 1664.9 D
Formula: C72H85N19O18S5
Purity: >95%
Format: Solid

Database Information

CAS : 1393-48-2| Matching products
KEGG ID : K09406 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302
P Phrases: P264, P270, P330, P301+P310, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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