Prolyl-glycyl-proline Peptide

Prolyl-glycyl-proline Peptide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11188-5 5 mg -

6 - 10 business days*

109.00€
Cay11188-25 25 mg -

6 - 10 business days*

477.00€
 
Proline-glycine-proline (PGP) is a tripeptide molecule and an established biomarker for chronic... more
Product information "Prolyl-glycyl-proline Peptide"
Proline-glycine-proline (PGP) is a tripeptide molecule and an established biomarker for chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). PGP functions as a neutrophil chemoattractant and is derived from the proteolytic cleavage of collagen in the extracellular matrix by a multistep cascade. First, the matrix metalloproteases MMP-8 or MMP-9 cleave collagen to peptides 30-100 amino acids in length. Prolyl endopeptidase further cleaves the collagen fragments to PGP. PGP and the related peptide N-acetylated PGP (Cay-11189) act through chemokine receptors CXCR1 and CXCR2 on neutrophil cells. Patients with cystic fibrosis have been shown to have elevated levels of PGP peptides in sputum. PGP, but not N-acetylated PGP, has been demonstrated to be a substrate for the pro-inflammatory enzyme LTA4 hydrolase.Synonyms: PGP. Formula Weight: 269.3. Purity: >95% by HPLC. Amino Acids: PGP. Formulation: (Request formulation change), A lyophilized powder. Solubility: Acetic Acid (80%): 50 mg/ml.
Keywords: PGP
Supplier: Cayman Chemical
Supplier-Nr: 11188

Properties

Conjugate: No
MW: 269.3 D
Purity: >95% by HPLC
Format: Solid

Database Information

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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