PAR3 (1-6) (human)

PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.Formal Name: L-threonyl-L-phenylalanyl-L-arginylglycyl-L-alanyl-L-proline. CAS Number: 320347-28-2. Synonyms: TFRGAP. Molecular Formula: C29H45N9O8. Formula Weight: 647.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: [H]N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N1CCC[C@H]1C(O)=O)=O)C)=O)=O)=O)CC2=CC=CC=C2)=O. InChi Code: InChI=1S/C29H45N9O8/c1-16(27(44)38-13-7-11-21(38)28(45)46)35-22(40)15-34-24(41)19(10-6-12-33-29(31)32)36-25(42)20(14-18-8-4-3-5-9-18)37-26(43)23(30)17(2)39/h3-5,8-9,16-17,19-21,23,39H,6-7,10-15,30H2,1-2H3,(H,34,41)(H,35,40)(H,36,42)(H,37,43)(H,45,46)(H4,31,32,33)/t16-,17+,19-,20-,21-,23-/m0/s1. InChi Key: LGNVPMUJJJLQHG-WZZXNIEWSA-N.