Kinetensin (human) (trifluoroacetate salt)

Kinetensin is a nonapeptide that has been found in pepsin-treated human plasma. It binds to neurotensin receptors in HT-29 cells and mouse brain (Kis = 1,396 and 149.6 nM, respectively, in radioligand binding assays) but does not induce the accumulation of intracellular calcium in HT-29 cells (EC50 = >10,000 nM). It induces histamine release in isolated rat peritoneal mast cells with an EC50 value of approximately 10 µM. Intradermal administration of kinetensin induces vascular permeability in rats.Formal Name: L-isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-leucine, trifluoroacetate salt. Synonyms: IARRHPYFL, Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu. Molecular Formula: C56H85N17O11 . XCF3COOH. Formula Weight: 1172.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 2 mg/ml. SMILES: CC[C@H](C)[C@H](N)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CN=CN1)C(N2[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)CCC2)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C56H85N17O11.C2HF3O2/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3,3-2(4,5)1(6)7/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64),(H,6,7)/t32-,33-,38-,39-,40-,41-,42-,43-,44-,45-,/m0./s1. InChi Key: HWZXQUSPWVIRMH-PFYQBJFCSA-N.