CAP 3

CAP 3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay27505-1 1 mg -

6 - 10 business days*

84.00€
Cay27505-5 5 mg -

6 - 10 business days*

381.00€
Cay27505-10 10 mg -

6 - 10 business days*

719.00€
 
CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against... more
Product information "CAP 3"
CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 µM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 µM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 µM.Formal Name: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-5-(benzyloxy)-5-oxopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triyl tris(2-((S)-2-amino-3-methylbutanamido)acetate). CAS Number: 2292123-03-4. Molecular Formula: C52H82N6O11. Formula Weight: 967.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5mg/mL, DMSO: 10mg/mL, Ethanol: 10mg/mL, PBS (pH 7.2): 3mg/mL. SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(OCC3=CC=CC=C3)=O)([H])[C@]4([H])[C@H](OC(CNC([C@@H](N)C(C)C)=O)=O)C[C@]5([H])C[C@H](OC(CNC([C@@H](N)C(C)C)=O)=O)CC[C@]5(C)[C@@]4([H])C[C@@H]1OC(CNC([C@@H](N)C(C)C)=O)=O. InChi Code: InChI=1S/C52H82N6O11/c1-28(2)45(53)48(63)56-24-41(60)67-34-19-20-51(8)33(21-34)22-38(68-42(61)25-57-49(64)46(54)29(3)4)44-36-17-16-35(31(7)15-18-40(59)66-27-32-13-11-10-12-14-32)52(36,9)39(23-37(44)51)69-43(62)26-58-50(65)47(55)30(5)6/h10-14,28-31,33-39,44-47H,15-27,53-55H2,1-9H3,(H,56,63)(H,57,64)(H,58,65)/t31-,33+,34-,35-,36+,37+,38-,39+,44+,45+,46+,47+,51+,52-/m1/s1. InChi Key: XOMVHDKAGAIFOU-ZJADFBSCSA-N.
Keywords: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-5-(benzyloxy)-5-oxopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triyl tris(2-((S)-2-amino-3-methylbutanamido)acetate)
Supplier: Cayman Chemical
Supplier-Nr: 27505

Properties

Application: Antibacterial cholic acid-peptide conjugate (CAP)
Conjugate: No
MW: 967.3 D
Formula: C52H82N6O11
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 2292123-03-4| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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