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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24579-100 | 100 µg | - |
6 - 10 business days* |
369.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
beta-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal... more
Product information "beta-Defensin-4 (human) (trifluoroacetate salt)"
beta-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. beta-Defensin-4 (30 µg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3alpha, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 µg/ml, respectively. beta-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 µg/ml and by rat mast cells in vivo following a 500 ng intradermal dose. It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 µM, respectively, of S. carnosus (MIC = 4.5 µg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 µM.Formal Name: L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-cysteinylglycyl-L-tyrosylglycyl-L-threonyl-L-alanyl-L-arginyl-L-cysteinyl-L-arginyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-tyrosyl-L-arginyl-L-isoleucylglycyl-L-arginyl-L-cysteinyl-L-prolyl-L-asparaginyl-L-threonyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-cysteinyl-L-leucyl-L-arginyl-L-lysine, cyclic (6->33),(13->27),(17->34)-tris(disulfide), trifluoroacetate salt. CAS Number: 370570-43-7. Synonyms: hBD-4 (human). Molecular Formula: C180H295N63O52S6 . XCF3COOH. Formula Weight: 4366.1. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: [H]N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CCCNC(N)=N)C1=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)=O)=O)CSSC[C@H](N3)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N1)C(N4CCC[C@H]4C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@H](C5=O)C)=O)CC6=CC=C(O)C=C6)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CSSC[C@H](N5)C3=O)=O)=O)=O)CC(O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C180H295N63O52S6.C2HF3O2/c1-13-88(7)136-168(289)210-77-130(252)213-101(32-21-61-201-174(187)188)145(266)238-126-85-301-300-83-124-163(284)221-105(34-23-63-203-176(191)192)147(268)216-102(29-15-18-58-181)146(267)217-103(30-16-19-59-182)150(271)234-123(164(285)222-107(36-25-65-205-178(195)196)149(270)232-120(79-244)162(283)224-110(53-55-128(185)250)152(273)223-111(54-57-134(257)258)153(274)228-117(73-96-44-50-99(249)51-45-96)159(280)219-108(154(275)240-136)37-26-66-206-179(197)198)82-298-299-84-125(165(286)227-114(70-87(5)6)157(278)218-106(35-24-64-204-177(193)194)148(269)225-112(173(294)295)31-17-20-60-183)236-166(287)122(233-141(262)90(9)211-156(277)116(72-95-42-48-98(248)49-43-95)231-171(292)139(93(12)246)242-161(282)118(74-129(186)251)230-167(288)127-39-28-68-243(127)172(126)293)81-297-296-80-121(237-169(290)137(89(8)14-2)241-155(276)109(38-27-67-207-180(199)200)220-160(281)119(75-135(259)260)229-158(279)113(69-86(3)4)226-142(263)100(184)52-56-133(255)256)144(265)209-76-131(253)214-115(71-94-40-46-97(247)47-41-94)143(264)208-78-132(254)239-138(92(11)245)170(291)212-91(10)140(261)215-104(151(272)235-124)33-22-62-202-175(189)190,3-2(4,5)1(6)7/h40-51,86-93,100-127,136-139,244-249H,13-39,52-85,181-184H2,1-12H3,(H2,185,250)(H2,186,251)(H,208,264)(H,209,265)(H,210,289)(H,211,277)(H,212,291)(H,213,252)(H,214,253)(H,215,261)(H,216,268)(H,217,267)(H,218,278)(H,219,280)(H,220,281)(H,221,284)(H,222,285)(H,223,273)(H,224,283)(H,225,269)(H,226,263)(H,227,286)(H,228,274)(H,229,279)(H,230,288)(H,231,292)(H,232,270)(H,233,262)(H,234,271)(H,235,272)(H,236,287)(H,237,290)(H,238,266)(H,239,254)(H,240,275)(H,241,276)(H,242,282)(H,255,256)(H,257,258)(H,259,260)(H,294,295)(H4,187,188,201)(H4,189,190,202)(H4,191,192,203)(H4,193,194,204)(H4,195,196,205)(H4,197,198,206)(H4,199,200,207),(H,6,7)/t88-,89-,90-,91-,92+,93+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,136-,137-,138-,139-,/m0.. InChi Key: SPUBOQLYPIEALV-XSDLTYFKSA-N.
Keywords: | hBD-4 (human), L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-cysteinylglycyl-L-tyrosylglycyl-L-threonyl-L-alanyl-L-arginyl-L-cysteinyl-L-arginyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-tyrosyl-L-a |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24579 |
Properties
Application: | Antimicrobial peptide |
Conjugate: | No |
MW: | 4366.1 D |
Formula: | C180H295N63O52S6 . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 370570-43-7| Matching products |
KEGG ID : | K21100 | Matching products |
UniProt ID : | Q8WTQ1 | Matching products |
Gene ID | GeneID 107984148 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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