beta-Defensin-2 (human) (trifluoroacetate salt)

beta-Defensin-2 (human) (trifluoroacetate salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay24577-100 100 µg -

6 - 10 business days*

488.00€
 
beta-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal... more
Product information "beta-Defensin-2 (human) (trifluoroacetate salt)"
beta-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of periodontopathogenic and cariogenic bacteria, including P. gingivalis and S. salivarius. beta-Defensin-2 (30 µg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3alpha, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 µg/ml, respectively. beta-Defensin-2 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 µg/ml and by rat mast cells in vivo following a 500 ng intradermal dose. Expression of beta-defensin-2 is increased in psoriatic skin and chronic wounds.Formal Name: glycyl-L-isoleucylglycyl-L-alpha-aspartyl-L-prolyl-L-valyl-L-threonyl-L-cysteinyl-L-leucyl-L-lysyl-L-serylglycyl-L-alanyl-L-isoleucyl-L-cysteinyl-L-histidyl-L-prolyl-L-valyl-L-phenylalanyl-L-cysteinyl-L-prolyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-glutaminyl-L-isoleucylglycyl-L-threonyl-L-cysteinylglycyl-L-leucyl-L-prolylglycyl-L-threonyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-lysyl-L-proline, cyclic (8->37),(15->30),(20->38)-tris(disulfide), trifluoroacetate salt. Synonyms: hBD-2. Molecular Formula: C188H305N55O50S6. XCF3COOH. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: [H]NCC(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@]([C@@H](C)O)([H])C4=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)CSSC[C@H](N6)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N7CCC[C@H]7C(O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)CC9=CN=CN9)=O)CSSC[C@H](N4)C(NCC(N[C@@H](CC(C)C)C(N%10CCC[C@H]%10C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C%11=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)CSSC[C@H](N%11)C6=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C188H305N55O50S6.C2HF3O2/c1-19-99(12)146(231-137(250)80-194)173(279)206-84-140(253)211-123(79-143(256)257)184(290)241-71-40-54-134(241)172(278)235-145(98(10)11)176(282)238-151(105(18)247)180(286)229-128-91-297-295-90-127-168(274)226-126(165(271)215-111(45-26-31-63-190)157(263)219-117(48-29-34-66-193)181(287)243-73-41-55-135(243)186(292)293)89-298-299-93-130-185(291)242-72-38-52-132(242)170(276)217-115(50-36-68-202-188(198)199)156(262)212-114(49-35-67-201-187(196)197)158(264)221-119(77-107-56-58-109(248)59-57-107)163(269)214-110(44-25-30-62-189)155(261)216-116(60-61-136(195)249)161(267)237-147(100(13)20-2)174(280)207-86-142(255)233-150(104(17)246)179(285)227-125(154(260)204-83-139(252)210-121(75-96(6)7)182(288)239-69-37-51-131(239)169(275)205-85-141(254)232-149(103(16)245)178(284)218-113(160(266)225-127)47-28-33-65-192)88-294-296-92-129(167(273)223-122(78-108-81-200-94-208-108)183(289)240-70-39-53-133(240)171(277)234-144(97(8)9)175(281)222-120(164(270)230-130)76-106-42-23-22-24-43-106)228-177(283)148(101(14)21-3)236-152(258)102(15)209-138(251)82-203-153(259)124(87-244)224-159(265)112(46-27-32-64-191)213-162(268)118(74-95(4)5)220-166(128)272,3-2(4,5)1(6)7/h22-24,42-43,56-59,81,94-105,110-135,144-151,244-248H,19-21,25-41,44-55,60-80,82-93,189-194H2,1-18H3,(H2,195,249)(H,200,208)(H,203,259)(H,204,260)(H,205,275)(H,206,279)(H,207,280)(H,209,251)(H,210,252)(H,211,253)(H,212,262)(H,213,268)(H,214,269)(H,215,271)(H,216,261)(H,217,276)(H,218,284)(H,219,263)(H,220,272)(H,221,264)(H,222,281)(H,223,273)(H,224,265)(H,225,266)(H,226,274)(H,227,285)(H,228,283)(H,229,286)(H,230,270)(H,231,250)(H,232,254)(H,233,255)(H,234,277)(H,235,278)(H,236,258)(H,237,267)(H,238,282)(H,256,257)(H,292,293)(H4,196,197,201)(H4,198,199,202),(H,6,7)/t99-,100-,101-,102-,103+,104+,105+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,144-,145-,146-,147-,148-,149-,150-,151-,/m0./s1. InChi Key: JJDUNZFWULIMFT-YIYXCTSTSA-N.
Keywords: hBD-2, glycyl-L-isoleucylglycyl-L-alpha-aspartyl-L-prolyl-L-valyl-L-threonyl-L-cysteinyl-L-leucyl-L-lysyl-L-serylglycyl-L-alanyl-L-isoleucyl-L-cysteinyl-L-histidyl-L-prolyl-L-valyl-L-phenylalanyl-L-cysteinyl-L-prolyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-
Supplier: Cayman Chemical
Supplier-Nr: 24577

Properties

Conjugate: No
MW: 4328.2 D
Formula: C188H305N55O50S6o XCF3COOH
Purity: >95%
Format: Solid

Database Information

UniProt ID : O15263 | Matching products
Gene ID GeneID 100289462 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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