ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. ACTH (4-10) is found in the septal nuclei, the third ventricle, and ventral horn motor neurons. The amino acid sequence of ACTH (4-10) is common to ACTH and the alpha- and beta-melanocyte stimulating hormones. ACTH (4-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 23 and 330 nM for the human recombinant receptors, respectively). It increases mean arterial pressure (ED50 = 287 nmol/kg) and heart rate (ED50 = 313 nmol/kg) in rats. It also improves aortic and coronary blood flow and left ventricular developed pressure following cardiac ischemia and reperfusion when administered at a dose of 200 µg/kg in rats, as well as reduces the infarct size and decreases caspase-3 activity. ACTH (4-10) (10 µg per animal) accelerates motor function improvements in a rat model of sciatic nerve crush.Formal Name: L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycine, trifluoroacetate salt. Synonyms: Adrenocorticotropic Hormone (4-10), Corticotropin (4-10). Molecular Formula: C44H59N13O10S . XCF3COOH. Formula Weight: 962.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: OC(C(F)(F)F)=O.[H]N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)CCSC. InChi Code: InChI=1S/C44H59N13O10S.C2HF3O2/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30,3-2(4,5)1(6)7/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49),(H,6,7)/t29-,31-,32-,33-,34-,35-,/m0./s1. InChi Key: ICCLJCOVWYXLTE-CZPFDPCBSA-N.