Product information "AAF-CMK (trifluoroacetate salt)"
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.
N-Ala-Ala-Phe-CMK, Tripeptidyl Peptidase Inhibitor II, L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-L-alaninamide, mono(trifluoroacetate)
TPPII inhibitor, Bleomycin hydrolase and aminopeptidase inhibitor