3,3',5'-Triiodo-L-thyronine

3,3',5'-Triiodo-L-thyronine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17598-5 5 mg -

6 - 10 business days*

114.00€
Cay17598-10 10 mg -

6 - 10 business days*

217.00€
Cay17598-25 25 mg -

6 - 10 business days*

509.00€
Cay17598-50 50 mg -

6 - 10 business days*

903.00€
 
3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by... more
Product information "3,3',5'-Triiodo-L-thyronine"
3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high serum levels of rT3 are found in neonates and in certain conditions. It reportedly activates TRDeltaalpha1, a native form of TRalpha that lacks a nuclear localization signal and functions in the cytoplasm. Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.Formal Name: O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine. CAS Number: 5817-39-0. Synonyms: Reverse T3, rT3, 3,3',5'-T3. Molecular Formula: C15H12I3NO4. Formula Weight: 651.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 211, 290 nm. SMILES: IC1=C(O)C(I)=CC(OC2=CC=C(C[C@H](N)C(O)=O)C=C2I)=C1. InChi Code: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1. InChi Key: HZCBWYNLGPIQRK-LBPRGKRZSA-N.
Keywords: 3,3',5'-T3, Reverse T3, rT3, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
Supplier: Cayman Chemical
Supplier-Nr: 17598

Properties

Application: TR Delta alpha1 activator
Conjugate: No
MW: 651 D
Formula: C15H12I3NO4
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 5817-39-0| Matching products
KEGG ID : K05547 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H332
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P312, P321, P330, P361+364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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